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Lymphocyte Development

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Figure: Myeloid-based model This model proposes that the developmental programs towards T, B and erythroid lineages proceed independently on the basis of the prototypical myeloid program. In hematopoiesis, pluripotent hematopoietic stem cells (HSC) are sequentially restricted to give rise to a variety of lineage-committed progenitors. The major aim of the Laboratory for Lymphocyte Development is to elucidate the molecular mechanisms that regulate cell fate decisions in the process of lineage restriction from HSC to unipotent progenitors. We have previously established a clonal assay system to examine the developmental potential of individual progenitor cells toward T, B and myeloid cell lineages. This work has led to the fundamental redefinition of lymphoid progenitors and the ontogeny and phylogeny of T and B cell development.