> Lymphocyte DevelopmentLymphocyte Development
Figure: Myeloid-based model
This model proposes that the developmental programs towards T, B and erythroid
lineages proceed independently on the basis of the prototypical myeloid program.
In hematopoiesis, pluripotent hematopoietic stem cells (HSC) are sequentially restricted to give rise to
a variety of lineage-committed progenitors. The major aim of the Laboratory for Lymphocyte Development
is to elucidate the molecular mechanisms that regulate cell fate decisions in the process of lineage
restriction from HSC to unipotent progenitors. We have previously established a clonal assay system to
examine the developmental potential of individual progenitor cells toward T, B and myeloid cell lineages.
This work has led to the fundamental redefinition of lymphoid progenitors and the ontogeny and phylogeny
of T and B cell development.