> Human Disease ModelHuman Disease Model
Laboratory for Human Disease Model
Current understanding of various biology including immunology has largely come
from the mouse studies.
However, it is becoming increasingly apparent that several aspects of human
immune system are different from those in the mouse, making clinical translation
of the knowledge gained from mouse research difficult.
In order to understand normal and diseased human immunity, direct in vivo
examination of human immune system is required. To this end,we have developed
humanized mice reconstituted human immunity in mice. Humanized mouse system
enables us to investigate differentiation, mobilization, and function of human
immunity in thymus, spleen, and LNs. In addition to the understanding of normal
human immunity, we are currently developing various models of human diseases such
as leukemia, infectious diseases, and primary immuno-deficiencies. We aim to
overcome intractable human diseases through understanding of the in vivo
pathophysiology of these diseases.