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Human Disease Model
Curriculum Vitae Fumihiko Ishikawa, MD, PhD. Personal Information Group Director Laboratory for Human Disease Model RIKEN Center for Allergy and Immunology (RCAI) Date of Birth: 1972/04/12 (39 y.o.) Degree 1995 October: United States Medical License Examination Step 1 (Basic Medical Science) passed 1996 November: United States Medical License Examination Step 2 (Clinical Medical Science) passed 1997 May: Japan Medical License Examination (M.D.) passed 2003 March 25th: Ph.D. (Kyushu University) Educational/Professional Background 1991: Admission to Kyushu University Medical School 1997 Mar.: Graduation from Kyushu University Medical School 1997 Apr.: Residency training at First Department of Medicine, Kyushu University 1997 Oct: Residency training at Third Department of Medicine, Kyushu University 1998 Apr-2000 Sep and 2002 Apr-2003 Mar：Kyushu University Graduate School of Medical Sciences 1998 Oct- 2002 Mar：Medical University of South Carolina, Department of Medicine, Division of Experimental Hematology (Makio Ogawa lab), Post-doctoral fellow 2003 Apr-2005 Mar：Japan Society for Promotion of Science, Post-doctoral fellow 2005 Apr-2005 Dec: Instructor, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences 2006 Jan - 2011 Dec: Unit leader, Research Unit for Human Disease Model, RCAI 2011 Dec - present: Group Director, Laboratory for Human Disease Model, RCAI Awards 64th Japan Society of Hematology Meeting, Young Investigator Award 2007 2006 RIKEN RCAI Outstanding Contribution of the Year 2008 2007 RIKEN RCAI Excellent Paper of the Year 2008 Takeda Science Foundation Grant support [I] 2008 2009 Ministry of Education, Sports, Science, and Technology. Young Scientist Award 2010 2009 RIKEN RCAI Outstanding Contribution of the Year 2010 2009 RIKEN RCAI Excellent Paper of the Year Review and Editorial Activity 2008-present: Leukemia editorial board member Recent Selected Publications 1.Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice. Proceedings of the National Academy of Sciences of the United States of America 107-29:13022-13027, 2010 2.Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nature Biotechnology 28-3:275-280, 2010 3.Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasaza M, Tanaka S, Takagi S, Uchida N, Suzuki N, Sone A, Najima Y, Ozawa H, Wake A, Taniguchi S, Shultz LD, Ohara O, Ishikawa F. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Science Translational Medicine 2-17:17ra9,2010 4.Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz L D. Chemotherapy-resistant human AML stem cells home to and engraft within the bone marrow endosteal region. Nature Biotechnology 25:1315-1321, 2007 5.Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nature Reviews Immunology 7:118-130, 2007 6.Ishikawa, F., M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe,K. Akashi, L.D. Shultz, and M. Harada. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice. Blood 106:1565-1573, 2005 7.Ishikawa, F., C.J. Drake, S. Yang, P. Fleming, H. Minamiguchi, R.P. Visconti, C.V. Crosby, W.S. Argraves, M. Harada, L.L. Key, Jr., A.G. Livingston, J.R. Wingard, and M. Ogawa. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci 996:174-185, 2003 8.Ishikawa, F., A.G. Livingston, J.R. Wingard, S. Nishikawa, and M. Ogawa.An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2-microglobulin(null) mice. Exp Hematol 30:488-494, 2002
Human Disease Model
CV-F Ishikawa
Curriculum Vitae Fumihiko Ishikawa, MD, PhD. Personal Information Group Director Laboratory for Human Disease Model RIKEN Center for Allergy and Immunology (RCAI) Date of Birth: 1972/04/12 (39 y.o.) Degree 1995 October: United States Medical License Examination Step 1 (Basic Medical Science) passed 1996 November: United States Medical License Examination Step 2 (Clinical Medical Science) passed 1997 May: Japan Medical License Examination (M.D.) passed 2003 March 25th: Ph.D. (Kyushu University) Educational/Professional Background 1991: Admission to Kyushu University Medical School 1997 Mar.: Graduation from Kyushu University Medical School 1997 Apr.: Residency training at First Department of Medicine, Kyushu University 1997 Oct: Residency training at Third Department of Medicine, Kyushu University 1998 Apr-2000 Sep and 2002 Apr-2003 Mar：Kyushu University Graduate School of Medical Sciences 1998 Oct- 2002 Mar：Medical University of South Carolina, Department of Medicine, Division of Experimental Hematology (Makio Ogawa lab), Post-doctoral fellow 2003 Apr-2005 Mar：Japan Society for Promotion of Science, Post-doctoral fellow 2005 Apr-2005 Dec: Instructor, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences 2006 Jan - 2011 Dec: Unit leader, Research Unit for Human Disease Model, RCAI 2011 Dec - present: Group Director, Laboratory for Human Disease Model, RCAI Awards 64th Japan Society of Hematology Meeting, Young Investigator Award 2007 2006 RIKEN RCAI Outstanding Contribution of the Year 2008 2007 RIKEN RCAI Excellent Paper of the Year 2008 Takeda Science Foundation Grant support [I] 2008 2009 Ministry of Education, Sports, Science, and Technology. Young Scientist Award 2010 2009 RIKEN RCAI Outstanding Contribution of the Year 2010 2009 RIKEN RCAI Excellent Paper of the Year Review and Editorial Activity 2008-present: Leukemia editorial board member Recent Selected Publications 1.Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice. Proceedings of the National Academy of Sciences of the United States of America 107-29:13022-13027, 2010 2.Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nature Biotechnology 28-3:275-280, 2010 3.Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasaza M, Tanaka S, Takagi S, Uchida N, Suzuki N, Sone A, Najima Y, Ozawa H, Wake A, Taniguchi S, Shultz LD, Ohara O, Ishikawa F. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Science Translational Medicine 2-17:17ra9,2010 4.Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz L D. Chemotherapy-resistant human AML stem cells home to and engraft within the bone marrow endosteal region. Nature Biotechnology 25:1315-1321, 2007 5.Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nature Reviews Immunology 7:118-130, 2007 6.Ishikawa, F., M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe,K. Akashi, L.D. Shultz, and M. Harada. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice. Blood 106:1565-1573, 2005 7.Ishikawa, F., C.J. Drake, S. Yang, P. Fleming, H. Minamiguchi, R.P. Visconti, C.V. Crosby, W.S. Argraves, M. Harada, L.L. Key, Jr., A.G. Livingston, J.R. Wingard, and M. Ogawa. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci 996:174-185, 2003 8.Ishikawa, F., A.G. Livingston, J.R. Wingard, S. Nishikawa, and M. Ogawa.An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2-microglobulin(null) mice. Exp Hematol 30:488-494, 2002