An important mission of our research unit is to develop and maintain an open resource bioinformatics platform and data resources in order to gain insights into Primary immunodeficiency diseases (PID) through genomic, transcriptomic, proteomic data. Our ultimate goal is to provide relevant, up-to-date and validated information on PID as per global community standards in an easily decipherable and usable format.
Primary immunodeficiency diseases (PIDs) are genetic disorders resulting in abnormalities in development and maintenance of immune system and manifested as increased susceptibility to infections and autoimmunedisorders. In general, PIDs are monogenic disorders that follow a simple Mendelian inheritance; however, some PIDs have a more complex polygenic origin. Patients with these intrinsic defects may have increased susceptibility to recurrent and persistentinfections and, in some cases, elevated susceptibility to autoimmune diseases and cancer. Our main aim is to bring together the clinicians and basic researchers in Asia who are interested in PID. We have recently developed an open access database on PID designated as “Resource of Asian Primary Immunodeficiency Diseases – RAPID”, a web-based compendium of molecular alterations and gene expression at the mRNA and protein levels of all primary immunodeficiency disease genes reported from PID patients. The database also includes other pertinent information about protein- protein interactions, mouse studies and microarray gene expression profiles in various organs and cells of the immune system and it can be accessed at http://rapid.rcai.riken.jp
The PID project has been initiated in collaboration with the Institute of Bioinformatics (IOB, Bangalore, India), the Immunogenomics research group at RIKEN RCAI, Japan and the Kazusa DNA Research Institute(KDRI),Japan in April, 2007.
This project was supported by The Asia S&T Strategic Cooperation Promotion Program, Special Coordination Funds for Promoting Science and Technology by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) until March 2010. As an independent research unit, our laboratory is now supported by RCAI.
Integrated Arthritis database (IntARTdB) is a web based compendium of high-throughput data on Arthritis. It serves as an integrated platform for arthritis-specific data collection, storage, annotation and analysis of genomics, transcriptomics, proteomics, metabolomics and other omics studies. IntARTdB framework is based on the constructed model-view-controller architecture. The data annotation tool is made available to the registered users, with controlled access privilege, to those who contribute high-throughput analyzed data to IntARTdB. To manage the high-throughput data file archives, we use Proteome Commons Tranche repository. This is the joint collaborative project initiated between Mohan lab at Research Unit for Immunoinformatics, RCAI, RIKEN, Japan and Gobezie lab at Musculoskeletal Proteomics, The Case Center for Proteomics and Systems Biology, Case Western Reserve University - School of Medicine,USA.