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Signal Network

List of publication in last 5 years
2007 1. Kano, S., Sato, K., Morishita, Y., Vollstedt, S., Kim, S., Taki, S., Honda, K., Kubo, M., & Taniguchi, T.,; Regulation of Th1 vs. Th17 differentiation: Selective contribution of thetranscription factor IRF1 to the IFN--IL-12 axis of signaling networks in CD4+ T cells. Nature Immunology, in press 2. Yagi, R., Tanaka, S., Motomura, Y., and Kubo, M., The regulation of Il4 gene expression in mast cells and basophils is regulated by distinct proximal and distal 3’ enhancers. Mol. Cell. Biol. in press 3. Kubo, M., Notch: filling a hole in T helper 2 cell differentiation. Immunity 27, 3-5, 2007 4. Yoshimura, A., Naka, T., Kubo, M.; SOCS proteins, cytokine signalling and immune regulation. Nature Review Immunology 7, 454-465, 2007 5. Hijikata, A, Kubo, M. et al. Construction of an open-access database that integrates crossreference information from the transcriptome and proteome of immune cells, Bioinformatics, 2007 Sep 25; 6. Fujita, S., Sato, Y., Sato, K., Eizumi, K., Kubo, M. Fukaya, T., and Sato, K., Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells. Blood, 2007 Aug 8 7. Kitazawa, Y., Fujino, M., Wang, Q., Kimura, H., Azuma, M., Kubo, M., Abe, R., and Li, X-K., Involvement of the Programmed Death-1/Programmed Death-1 Ligand Pathway in CD4-CD25- Regulatory T-Cell Activity to Suppress Alloimmune Responses, Transplantation 83: 774–782, 2007 8. Numata, K., Kubo, M., Watanabe, H., Takagi, K., Mizuta, H., Okada, S., Ito, T., and Matsukawa, A., ; Overexpression of Suppressor of Cytokine Signaling-3 in T cells Exacerbates Acetaminophen–induced Hepatotoxicity. J. Immunol. 178 3777-3785, 2007 9. Inoue, H., Fukuyama, S., Kubo, M., and Yoshimura, A., ; Role of endogenous inhibitors of cytokine signaling in allergic asthma, Current Medicinal Chemistry 14, 181-189, 2007 10. Seki, Y., Yang, J., Okamoto, M., Tanaka, S., Goizuka, Farrar, M.A., R., and Kubo, M., ; The role of IL-7/STAT5 pathway and suppressor of cytokine signaling 1 in maintenance of naive and memory CD4 T cells in peripheral lymphoid organs. J. Immunol. 1;178(1):262-70, 2007 2006 1. Watanabe, H., Kubo, M., Numata, K., Takagi, K., Mizuta, H., Okada, S., Ito, T., and Matsukawa, A.,; Overexpression of Suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol. 15;177(12):8650-8657, 2006 2. Tanaka, S., Tsukada, J., Suzuki, W., Hayashi, K., Tanigaki, K., Tsuji, M., Honjo, T., Kubo, M: IL-4 3’ enhancer transduces Notch signals to activate initial IL-4 expression in NKT cells and memory phenotype CD4 T cells.Immunity 24, 689–701, 2006 3. Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H., and Nakanishi, K., ; Contribution of interleukin-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. Proc. Natl. Acad. Sci. USA 103: 8816-8821, 2006 4. Kubo, M, Ozaki, A., Tanaka, S., Okamoto, M., Fukushima, A.; SOCS proteins in Ocular Allergy, Current Opinion in Allergy & Clinical Immunology 6, 361-366,2006 5. Kubo, M., Inoue, H., Suppressor of Cytokine Signaling 3 (SOCS3) in the Th2 cells evokes Th2 cytokines, IgE and eosinophilia, Current Allergy and Asthma Reports 9, 32-39, 2006 6. Inagaki-Ohara, K., Sasaki, A., Matsuzaki, G., Ikeda, T., Sakamoto, Y., Hotokezaka, M., Chijiiwa, K., Nawa, Y., Kubo, M., Yoshida, H., and Yoshimura A.,: Suppressor of cytokine signaling-1 in lymphocytes regulates development of experimental colitis and inflammatory bowel disease、Gut 55, 212-219, 2006 7. Nagai, H., Kubo, M., Abe, R., Yamamoto, M., and Nohara., K., Activation of the aryl hydrocarbon receptor in the thymocytes induces thymocyte reduction independently of Fas/Fas ligand signaling pathway. International Immunopharmacology 6, 276-286, 2006 8. Yamada, S., Tsukada, J., Yoshimura, A, and Kubo, M.: Computer Simulation of the Role of SOCS Family Protein in T Helper Cell Differentiation. Int. Immunol. 18, 335-345, 2006 2005 1. Ozaki, A., Seki, Y., Fukushima, A., Kubo, M., The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS) 3 and SOCS5. J. Immunol. 175, 5489-5497, 2005 2. Tsukada, J, Ozaki, A., Hanada, T., Chinen, T., Abe, R., Yoshimura, A, Kubo, M.: The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8+ dendritic cell subset. Int. Immunol. 17, 1167–1178, 2005 3. Tanaka, G., Kanaji, S., Hirano, A., Arima, K., Shinagawa, A., Goda, C., Yasunaga, S., Ikizawa, K., Yanagihara, Y., Kubo, M., Kuriyama-Fujii, Y., Sugita, Y., Inokuchi, A., and Izuhara, K.,: Induction and Activation of the Aryl Hydrocarbon Receptor by Interlukin-4 in B cells. Int. Immunol. 17, 797-805, 2005 4. Yoshida, N-L., Nagata, N., Sugita, Y., Arai, T., Seki, Y., Kubo, M., Tsujimoto, G., Akasawa, A., Saito,H., Oshida, T. : Mite-antigen stimulation of MAL expression in peripheral blood T cell of atopic patients. Allergology International 54,273-282, 2005 5. Hanada, T., Tanaka, K., Matsumura, Y., Nishinakamura, H., Aburatani, H., Mashima, R., Kubo, M., Kobayashi, T., Yoshimura, A. Induction of T-helper (Th1) cell type immune response by dendritic cells lacking the suppressors of cytokine signaling-1 (SOCS1) gene. J. Immunol. 174, 4325-4332, 2005 6. Takatori, H., Nakajima, H., Hirose, K., Kagami, S., Suto, A., Suzuki, K., Kubo, M., Yoshimura, A., Saito, Y., and Iwamoto, I.: Stat5a Inhibits IL-12-induced Th1 Cell Differentiation through the Induction of SOCS3 Expression. J. Immunol. 174, 4105-4112, 2005 7. Watanabe, M., Watanabe, S., Hara, Y., Suzuki, K., Tezuka, K., Harada, Y., Kubo, M., Tanabe, K., Toma, H., Abe, R., ICOS mediated co-stimulation on Th2 differentiation activated by the enhancement of IL-4 receptor mediated signaling. J. Immunol. 174, 1989-1996, 2005 8. Nagai, H., Takei, T., Tohyama, C., Kubo, M., Abe, R., and Nohara, K., A search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice  Int Immunopharmacol. 2, 331-343. 2005 9. Inoue, H., Fukuyama, S., Kato, R., Matsumoto, K., Nakao, T., Tsuda, M., Yoshida, Y., Kubo, M., Takatsu, K., Nakanishi, Y., Yoshimura, A.: Spred-1 negatively regulates allergen-induced eosinophilia and hypersensitiveness J. Exp. Med. 201, No.1: 73-82, 2005 2004 1. Inoue, H., Kubo, M. : SOCS proteins in T helper cell differentiation: implication for allergic disorder. Expert Reviews in Molecular Medicine, 6:22:1-11, 2004 2. Sasanuma, H., Tatsuno, A., Tsuji, K., Hidano, S., Morita, S., Kitamura, T., Kubo, M., Kitamura, D., Goitsuka, R.,: Transcriptional regulation of SLP-76 family hematopoietic cell adaptor MIST/Clink by STAT5. Biochem. Biophys. Res. Commun. 321, 145-153, 2004 3. Tanigaki, K., Tsuji, M., Han, H., Yamamoto, N., Tsukada, J., Inoue, H., Kubo, M., Honjo, T.: Regulation of  T cell lineage commitment and peripheral T cell response by Notch/RBP-J signaling. Immunity 20, 611-622, 2004 4. Seki, N., Suzuki, W., Hayashi, K., Miyazaki, M., Izuhara, K., Brombacher, F., and Kubo, M. : IL-4-induced GATA-3 expression is a time-restricted instruction switch for type 2 helper T cell differentiations. J. Immunol. 172, 6158-6166, 2004 5. Tokoyoda, K., Tsujikawa, K., Ono, Y., Matsushita, H., Hayashi, T., Harada, Y., Abe, R., Kubo, M., and Yamamoto, H. : Up-regulation of IL-4 production by the activated cAMP/PKA pathway in CD3/CD28-stiulated naïve T cells. Int. Immunol. 16, 5, 643-653, 2004 2003 1. Kubo, M., Hanada, T, Yoshimura, A.: Suppressor of cytokine signaling and immunity, Nature Immunology 4 (12), 1169-1176, 2003 2. Hanada, T., Inagaki-Ohara, K., Yoshida, H., Kato, S., Tsukada, J., Nomura, Y., Mimata, H., Kubo, M., and Yoshimura, A.; Suppressor of cytokine signaling-1 (SOCS1) is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19 (9), 437-450, 2003 3. Seki, Y., Inoue, H., Nagata, N., Hayashi, K., Satoru Fukuyama, S., Matsumoto, K., Komine,O., Hamano, S., Himeno, K., Inagaki, K., Cacalano, N., O'Garra, A., Oshida, T., Saito, H., Johnston, J.A., Yoshimura, A., and Kubo, M. :Suppressor of cytokine signaling-3 (SOCS3) regulates onset and maintenance of type 2 helper T cell mediated allergic responses. Nature Medicine 9, No.8, 1047-1054 2003 4. Komine, O., Hayashi, K., Natsume, W., Seki, Y., Seki, N., Yagi, R., Suzuki, W., Watanabe, T., Tamauchi, H., Hozumi, K., Habu, S., Satake, M., and Kubo, M.: The Runx1 transcription factor Inhibits the differentiation of naive CD4+ T Cells into the Th2 lineage by repressing GATA3 expression. J. Exp. Med. 198, No.1: 51-61, 2003 5. Matsumoto, A., Seki, Y., Watanabe, R., Hayashi, K., Johnston, J.A., Harada, Y., Abe, R., Yoshimura, A., and Kubo, M.: A role of Suppressor of Cytokine Signaling-3 (SOCS3/CIS3/SSI3) is CD28 mediated IL-2 production. J. Exp. Med. 197, No.4: 425-436, 2003