> Cell SignalingCell Signaling
Group Director：Takashi Saito
Immune response is triggered upon antigen recognition by T cells through T cell receptor
(TCR), and the activated T cells exhibit cell proliferation (clonal expansion) and functional
differentiation, and effector function. Signal transduction through TCR upon antigen recognition
regulates development, activation, and effector function of T cells through various signal
transduction pathways. Our group is focusing on the analyses of molecular mechanism of signal
regulation through TCR to induce such multiple functions of T cells, particularly activation and
Major projects currently analyzing are:
- TCR-mediated signaling and its regulation mechanism are analyzed through dynamic
molecular assembly as TCR signalsome for activation.
- Diversification of signaling pathways to induce different T cell function is analyzed
particularly for TCR-mediated NF-κB activation.
- The co-regulation of innate and acquired immunities is analyzed on molecules critical in
innate immunity for adaptive responses.
- Molecular mechanism of thymocyte development and selection is analyzed from the signaling
point of view.
These analyses are performed by employing new imaging tools at the single-cell and
single-molecule level as well as in vivo gene-targeting technology. Our final goal is to
develop immunological strategies by modulating signaling molecules to regulate
hyper-responses of T cells such as allergy and autoimmune diseases, and immune suppression
in cancer and transplantation.