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Cell Signaling
PUBLICATION LIST 2009 1. Yokosuka, T. and Saito, T.: Immunological synapse, TCR microclusters, and T cell activation. Curr. Topics. Microbiol. Immunol. in press. 2. Takeuchi, A., Itoh, Y., Takumi, A., Ishihara, C., Arase, N., Yokosuka, T., Koseki, H., Yamasaki, S., Takai, Y., Miyoshi, J., Ogasawara, K., Saito, T.: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J. Immunol. 183(7): 4220-4228, 2009. 3. Hara, S., Nakaseko, C., Yamasaki, S., Hattori, M., Bos, JL., Saito, Y., Minato, N., Saito, T.: Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal. Hematology. 2009 Jun;14(3):150-8. 4. Yokosuka, T. and Saito, T.: Dynamic regulation of T-cell costimulation through TCR-CD28 microclsters. Immunol. Rev. 229: 27-40, 2009 5. Takahama, Y., Saito, T., Kawamoto, H., Itoi, M., Boyd R.L., Chidgey, A., Zamoyska, R., Hollander, G.A., Anderson, G., Taylor, N., Petrie, H.T. and Nikolich-Zugich, J. : The global thymus network: past, preent and future. Trends Immunol. 30: 191-192, 2009 6. Hara, H. and Saito, T.: CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol. 30: 234-242, 2009 7. Takahashi, A., Obata, Y., Fukumoto, Y., Nakayama, Y., Kasahara, K., Kuga, T., Higashiyama, Y., Saito, T., Yokoyama, K.K. and Yamaguchi, N.: Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Exp. Cell Res. 315(7): 1117-1141, 2009 8. Sato, K., Eizumi, K., Fukaya, T., Fujita, S., Sato, Y., Takagi, H., Yamamoto, M., Yamashita, N., Hijikata, A., Kitamura, H., Ohara, O., Yamasaki, S., Saito, T. and Sato, K.: Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood, 113: 4780-4789, 2009 9. Shinohara, H., Yamasaki, S., Maeda, S., Saito, T. and Kurosaki, T.: Regulation of NF-kappa B-dependent T cell activation and development by MEKK3. Int. Immunol. 21(4): 393-401, 2009. 10. Sato, I., Obata, Y., Kasahara, K., Nakayama, Y., Fukumoto, Y., Yamasaki, T., Yokoyama, KK., Saito, T. and Yamaguchi, N.: Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J. Cell Sci. 122(7): 965-975 2009 11. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., Saito, T.: C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA. 10(6): 1897-1902, 2009 12. Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T., Taki, S.: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 10(2): 214-222, 2009 2008 1. Okada, S., Harada, H., Ito, T., Saito, T. and Suzu, S.: Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells. Int. J. Hematol. 88: 476-482, 2008. 2. Kometani, K., Moriyama, M., Nakashima, Y., Katayama, Y., Wang, S-F., Yamasaki, S., Saito, T., Hattori, M. and Minato, N.: Essential role of Rap signal in pre-TCR–mediated beta-selection checkpoint in arpha/beta T cell development. Blood. 112(12): 4565-4573, 2008. 3. Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M. and Saito, T.: Spatiotemporal regulation of T cell co-stimulation by TCR-CD28 microclusters through PKCθ translocation. Immunity. 29(4): 589-601, 2008 4. Yamasaki S, Takase-Utsugi M, Ishikawa E, Sakuma M, Nishida K, Saito T, Kanagawa O. Selective impairment of Fc{varepsilon}RI-mediated allergic reaction in Gads-deficient mice. Int Immunol. 2008 5. Jensen, K.D., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M.M., Baumgarth, N. and Chien, Y-H. : Thymic selection determines gd T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon g. Immunity. 29(1): 90-100, 2008. 6. Hara, H., Ishihara, C., Takeuchi, A., Xue, L., Morris, S.W., Penninger, J.M., Yoshida, H. and Saito, T.: Cell-type-specific regulation of ITAM-mediated NF-kB activation by adaptors, CARMA1 and CARD9. J. Immunol.181(2):918-930 2008. 7. Yamasaki, S. and Saito, T.: Progress in allergy signal research on mast cells: Signal regulation of multiple mast cell responses through Fc-epsilon-RI. J. Pharmacol. Sci. 106(3):336-340, 2008. 8. Baudino, L., Nimmerjahn, F., Azeredo da Silveira, S., Martinez-Soria, E., Saito, T., Carroll, M., Ravetch, J.V., Verbeek, J. S. and Izui, S.: Differential contribution of three activating IgG Fc receptors (Fc-gamma-RI, Fc-gamma-RIII and Fc-gamma-RIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J. Immunol. 180(3): 1948-1953, 2008. 2007 1. Suenaga, T., Arase, H., Yamasaki, S., Kohno, M., Yokosuka, T., Takeuchi, A., Hattori, T., and Saito, T.: Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. Eur. J. Immunol. 37(11): 3197-3207, 2007. 2. Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kubo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K., Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Sato, K., Seino, KI., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S., Ohara, O.: Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics. 23(21): 2934-2941, 2007. 3. Rabie, T., Varga-Szabo, D., Bender, M., Pozgaj, R., Lanza, F., Saito, T., Watson, S. P. and Nieswandt, B.: Diverging signaling events control the pathway of GPVI down-regulation in vivo. Blood.110(2): 529-535, 2007. 4. Imanishi, T., Hara, H., Suzuki, S., Suzuki, N., Akira, S. and Saito, T.: TLR2 directly triggers Th1 effector functions. J. Immunol. 178(11):6715-6719, 2007. 5. Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S.W., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H.,Penninger, J.M. and Saito, T.: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 8(6): 619-629, 2007. 6. Yamasaki, S., Ishikawa, E., Sakuma, M., Kanagawa, O., Cheng, A.M., Malissen, B. and Saito, T.: LAT and NTAL mediate Immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol. Cell. Biol. 27(12): 4406-4415, 2007. 7. Yamasaki, S. and Saito, T.: Molecular basis for pre-TCR-mediated autonomous signaling. Trends. Immunol.28(1): 39-43, 2007. 8. Suzuki, J-I., Yamasaki, S., Wu, J., Koretzky, G.A. and Saito, T.: The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood. 109(1): 168-175, 2007. 2006 1. Suzuki, N. and Saito, T.: IRAK-4⎯a shared NK-κB activator in innate and acquired immunity. Trends. Immunol. 27(12): 566-572, 2006. 2. Varma, R., Campi, G., Yokosuka, T., Saito, T. and Dustin, M.L.: T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25(1): 117-127, 2006. 3. Panov, K. I., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. and Zomerdijk, C. B. M.: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by UBF. Mol. Cell. Biol. 26(14): 5436-48, 2006. 4. Saito, T. and Yokosuka, T.: Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr. Opin. Immunol. 18(3):305-313, 2006. 5. Suzuki, N., Suzuki, S., Millar, D. G., Unno, M., Hara, H., Calzascia, T., Yamasaki, S., Yokosuka, T., Chen, N-J., Elford, A. R., Suzuki, J-I., Takeuchi, A., Mirtsos, C., Bouchard, D.,Ohashi, P. S., Yeh, W-C. and Saito, T.: A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311:1927-1932, 2006. 6. Yamasaki, S. Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L.,Tokunaga, M. and Saito, T.:Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7(1): 67-75, 2006. 2005 1. Yokosuka, T. Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto-Tane, A., Tokunaga, M.,Dustin, M.L. and Saito, T.: Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of ZAP 70 and SLP-76. Nat. Immunol. 6(12); 1253-1262, 2005. 2. Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H.: Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 175(7):4441-4449, 2005. 3. Masuda, K., Ouchida, R., Takeuchi, A., Saito, T., Koseki, H., Kawamura, K., Tagawa, M., Tokuhisa,T., Azuma, T. and O-Wang, J.: DNA polymerase contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc. Natl. Acad. Sci. USA. 102(39); 13986-13991, 2005. 4. Yamasaki S, Saito T.:Regulation of mast cell activation through FcRI. Saito H, Okayama Y (eds): Mast Cells in Allergic Diseases. Chem. Immunol. Allergy. Basel, Karger, 2005, vol 87, pp 22-31 5. Arase, N., Takeuchi, A., Unno, M., Hirano, S., Yokosuka, T., Arase, H. and Saito, T.: Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells. Int. Immunol. 17(9); 1227-1237, 2005. 6. Azumi, K., Sasaki, T., Okochi, K., Yamasaki, S., Saito, T., Takayama, H. and Yokosawa, H.: Differential display analysis reveals the expression of glutathione S-transferase and novel genes through an ITAM-containing receptor in ascidian immunocytes. Immunogenetics 57(6);444-452, 2005. 7. Hida, S., Tadachi, M., Saito, T. and Taki, S.: Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-2019, 2005. 8. Taki, S., Nakajima, S., Ichikawa, E., Saito, T. and Hida, S.: IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J. Immunol. 174; 6005-6012, 2005. 9. Linwong, W., Hirasawa, N., Aoyama, S., Hamada, H., Saito, T. and Ohuchi, K.: Inhibition of the antigen-induced activation of rodent maset cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br. J. Pharmacol. 145; 818-828, 2005. 10. Breij, E. C.W., Heijnen, P., Vloet, R., Saito, T., van de Winkel, J.G.J., Dijkstra, C. D., Amor, S. and Verbeek, S.: The FcR chain is not essential for induction of experimental allergic encephalomyelitis (EAE) or anti-myelin antibody-mediated exacerbation of EAE. J. Neuropathol. Exp. Neurol. 64(4); 304-311, 2005. 11. Kataoka, H., Takahashi, S., Takase, K., Yamasaki, S., Yokosuka, T., Koike, T. and Saito, T.: CD25+CD4+ regulatory T cells exert in vitro suppressive activity independently of CTLA-4. Int. Immunol. 17(4); 421-427, 2005. 12. Takahashi, S., Kataoka, H., Hara, S., Yokosuka, T., Takase, K., Yamasaki, S., Kobayashi, W., Saito, Y. and Saito, T.: In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection. Eur. J. Immunol. 35:399-407, 2005. 13. Suzuki, N., Suzuki, S. and Saito, T.: IRAKs: key regulatory kinases of innate immunity. Curr. Med. Chem. 4(1): 13-20, 2005. 14. Kohno, M., Yamasaki, S., Tybulewicz, VL. and Saito, T.: Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood. 105(5); 2059-2065, 2005.(the first two authors equally contributed.) 2004 1. Yamasaki, S. and Saito, T.: Inhibitory adaptors in lymphocytes. Semin. Immunol. 16(6): 421-427, 2004. 2. Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Xu W, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K.: The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int. Immunol. 16(12): 1691-9, 2004. 3. Hara, H., Bakai, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T. and Penninger, J. M.: The molecular adapter Carma1 controls entry of IKK into the central immune synapse. J. Exp. Med. 200(9):1167-1177, 2004. 4. Nakatsu, F., Okada, M., Mori, F., Kumazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T., Watanabe, M., Yuasa, S., Manabe, T., Wakabayashi, K., Kaneko, S., Saito, T., and Ohno, H.: Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J.Cell. Biol. 167(2): 293-302, 2004. 5. Tomassini, B., Malisan, F., Franchi, L., Nicolo, C., Brea-Calvo, G., Saito, T. and Testi, R.: Calnexin suppresses GD3 synthase-induced apoptosis. FASEB J. 18(13): 1553-1555, 2004. 6. Ishikawa, S., Arase, N., Suenaga, T., Saita, Y., Noda, M., Kuriyama, T., Arase, H. and Saito, T.: Involvement of FcRg in signal transduction of osteoclast-associated receptor (OSCAR). Int. Immunol. 16(7): 1019-1025, 2004. 7. Ohtsuka, M., Arase, H., Takeuchi, A., Yamasaki, S., Shiina, R., Suenaga, T., Sakurai, D., Yokosuka, T., Arase, N., Iwashima, M., Kitamura, T., Moriya, H., and Saito, T.: NFAM1, a new ITAM+ surface molecule that regulates development and signaling of B lymphocytes. Proc. Natl. Acad. Sci. USA 101(21): 8126-8131, 2004. 8. Ishizuka, M., Toyama, Y., Watanabe, H., Fujiki, Y., Takeuchi, A., Yamasaki, S., Yuasa, S., Miyazaki, M., Nakajima, N., Taki, S. and Saito, T.: Overexpression of human acyl CoA thioesterase upregulates peroxisome biogenesis. Exp. Cell. Res. 297(1): 127-141, 2004. 9. Yamasaki, S., Ishikawa, E., Kohno, M. and Saito, T.: The quantity and duration of FcR gamma signals determines mast cell degranulation and survival. Blood. 103(8): 3093-3101, 2004. 10. Kuroyama, H., Ikeda, T., Kasai, M., Yamasaki, S., Tatsumi, M., Utsuyama, M., Saito, T. and Hirokawa, K.: Identification of a novel isoform of ZAP-70, truncated ZAP kinase. Biochem. Biophys. Res. Commun. 315(4): 935-941, 2004. 11. Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L.: Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 199(4): 525-533, 2004. 12. Sakurai, D., Yamasaki, S., Arase, K., Park, S. Y., Arase, H., Konno, A. and Saito, T.: Fc epcilon RI gamma-immunoreceptor tyrosine-based activation motif is differentially required for mast cell function in vivo. J. Immunol. 172(4): 2374-2381 2004.
Cell Signaling
PUBLICATION LIST 2009 1. Yokosuka, T. and Saito, T.: Immunological synapse, TCR microclusters, and T cell activation. Curr. Topics. Microbiol. Immunol. in press. 2. Takeuchi, A., Itoh, Y., Takumi, A., Ishihara, C., Arase, N., Yokosuka, T., Koseki, H., Yamasaki, S., Takai, Y., Miyoshi, J., Ogasawara, K., Saito, T.: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J. Immunol. 183(7): 4220-4228, 2009. 3. Hara, S., Nakaseko, C., Yamasaki, S., Hattori, M., Bos, JL., Saito, Y., Minato, N., Saito, T.: Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal. Hematology. 2009 Jun;14(3):150-8. 4. Yokosuka, T. and Saito, T.: Dynamic regulation of T-cell costimulation through TCR-CD28 microclsters. Immunol. Rev. 229: 27-40, 2009 5. Takahama, Y., Saito, T., Kawamoto, H., Itoi, M., Boyd R.L., Chidgey, A., Zamoyska, R., Hollander, G.A., Anderson, G., Taylor, N., Petrie, H.T. and Nikolich-Zugich, J. : The global thymus network: past, preent and future. Trends Immunol. 30: 191-192, 2009 6. Hara, H. and Saito, T.: CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol. 30: 234-242, 2009 7. Takahashi, A., Obata, Y., Fukumoto, Y., Nakayama, Y., Kasahara, K., Kuga, T., Higashiyama, Y., Saito, T., Yokoyama, K.K. and Yamaguchi, N.: Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Exp. Cell Res. 315(7): 1117-1141, 2009 8. Sato, K., Eizumi, K., Fukaya, T., Fujita, S., Sato, Y., Takagi, H., Yamamoto, M., Yamashita, N., Hijikata, A., Kitamura, H., Ohara, O., Yamasaki, S., Saito, T. and Sato, K.: Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood, 113: 4780-4789, 2009 9. Shinohara, H., Yamasaki, S., Maeda, S., Saito, T. and Kurosaki, T.: Regulation of NF-kappa B-dependent T cell activation and development by MEKK3. Int. Immunol. 21(4): 393-401, 2009. 10. Sato, I., Obata, Y., Kasahara, K., Nakayama, Y., Fukumoto, Y., Yamasaki, T., Yokoyama, KK., Saito, T. and Yamaguchi, N.: Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J. Cell Sci. 122(7): 965-975 2009 11. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., Saito, T.: C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA. 10(6): 1897-1902, 2009 12. Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T., Taki, S.: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 10(2): 214-222, 2009 2008 1. Okada, S., Harada, H., Ito, T., Saito, T. and Suzu, S.: Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells. Int. J. Hematol. 88: 476-482, 2008. 2. Kometani, K., Moriyama, M., Nakashima, Y., Katayama, Y., Wang, S-F., Yamasaki, S., Saito, T., Hattori, M. and Minato, N.: Essential role of Rap signal in pre-TCR–mediated beta-selection checkpoint in arpha/beta T cell development. Blood. 112(12): 4565-4573, 2008. 3. Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M. and Saito, T.: Spatiotemporal regulation of T cell co-stimulation by TCR-CD28 microclusters through PKCθ translocation. Immunity. 29(4): 589-601, 2008 4. Yamasaki S, Takase-Utsugi M, Ishikawa E, Sakuma M, Nishida K, Saito T, Kanagawa O. Selective impairment of Fc{varepsilon}RI-mediated allergic reaction in Gads-deficient mice. Int Immunol. 2008 5. Jensen, K.D., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M.M., Baumgarth, N. and Chien, Y-H. : Thymic selection determines gd T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon g. Immunity. 29(1): 90-100, 2008. 6. Hara, H., Ishihara, C., Takeuchi, A., Xue, L., Morris, S.W., Penninger, J.M., Yoshida, H. and Saito, T.: Cell-type-specific regulation of ITAM-mediated NF-kB activation by adaptors, CARMA1 and CARD9. J. Immunol.181(2):918-930 2008. 7. Yamasaki, S. and Saito, T.: Progress in allergy signal research on mast cells: Signal regulation of multiple mast cell responses through Fc-epsilon-RI. J. Pharmacol. Sci. 106(3):336-340, 2008. 8. Baudino, L., Nimmerjahn, F., Azeredo da Silveira, S., Martinez-Soria, E., Saito, T., Carroll, M., Ravetch, J.V., Verbeek, J. S. and Izui, S.: Differential contribution of three activating IgG Fc receptors (Fc-gamma-RI, Fc-gamma-RIII and Fc-gamma-RIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J. Immunol. 180(3): 1948-1953, 2008. 2007 1. Suenaga, T., Arase, H., Yamasaki, S., Kohno, M., Yokosuka, T., Takeuchi, A., Hattori, T., and Saito, T.: Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. Eur. J. Immunol. 37(11): 3197-3207, 2007. 2. Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kubo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K., Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Sato, K., Seino, KI., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S., Ohara, O.: Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics. 23(21): 2934-2941, 2007. 3. Rabie, T., Varga-Szabo, D., Bender, M., Pozgaj, R., Lanza, F., Saito, T., Watson, S. P. and Nieswandt, B.: Diverging signaling events control the pathway of GPVI down-regulation in vivo. Blood.110(2): 529-535, 2007. 4. Imanishi, T., Hara, H., Suzuki, S., Suzuki, N., Akira, S. and Saito, T.: TLR2 directly triggers Th1 effector functions. J. Immunol. 178(11):6715-6719, 2007. 5. Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S.W., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H.,Penninger, J.M. and Saito, T.: The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 8(6): 619-629, 2007. 6. Yamasaki, S., Ishikawa, E., Sakuma, M., Kanagawa, O., Cheng, A.M., Malissen, B. and Saito, T.: LAT and NTAL mediate Immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol. Cell. Biol. 27(12): 4406-4415, 2007. 7. Yamasaki, S. and Saito, T.: Molecular basis for pre-TCR-mediated autonomous signaling. Trends. Immunol.28(1): 39-43, 2007. 8. Suzuki, J-I., Yamasaki, S., Wu, J., Koretzky, G.A. and Saito, T.: The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood. 109(1): 168-175, 2007. 2006 1. Suzuki, N. and Saito, T.: IRAK-4⎯a shared NK-κB activator in innate and acquired immunity. Trends. Immunol. 27(12): 566-572, 2006. 2. Varma, R., Campi, G., Yokosuka, T., Saito, T. and Dustin, M.L.: T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25(1): 117-127, 2006. 3. Panov, K. I., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. and Zomerdijk, C. B. M.: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by UBF. Mol. Cell. Biol. 26(14): 5436-48, 2006. 4. Saito, T. and Yokosuka, T.: Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr. Opin. Immunol. 18(3):305-313, 2006. 5. Suzuki, N., Suzuki, S., Millar, D. G., Unno, M., Hara, H., Calzascia, T., Yamasaki, S., Yokosuka, T., Chen, N-J., Elford, A. R., Suzuki, J-I., Takeuchi, A., Mirtsos, C., Bouchard, D.,Ohashi, P. S., Yeh, W-C. and Saito, T.: A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311:1927-1932, 2006. 6. Yamasaki, S. Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L.,Tokunaga, M. and Saito, T.:Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7(1): 67-75, 2006. 2005 1. Yokosuka, T. Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto-Tane, A., Tokunaga, M.,Dustin, M.L. and Saito, T.: Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of ZAP 70 and SLP-76. Nat. Immunol. 6(12); 1253-1262, 2005. 2. Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H.: Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 175(7):4441-4449, 2005. 3. Masuda, K., Ouchida, R., Takeuchi, A., Saito, T., Koseki, H., Kawamura, K., Tagawa, M., Tokuhisa,T., Azuma, T. and O-Wang, J.: DNA polymerase contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc. Natl. Acad. Sci. USA. 102(39); 13986-13991, 2005. 4. Yamasaki S, Saito T.:Regulation of mast cell activation through FcRI. Saito H, Okayama Y (eds): Mast Cells in Allergic Diseases. Chem. Immunol. Allergy. Basel, Karger, 2005, vol 87, pp 22-31 5. Arase, N., Takeuchi, A., Unno, M., Hirano, S., Yokosuka, T., Arase, H. and Saito, T.: Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells. Int. Immunol. 17(9); 1227-1237, 2005. 6. Azumi, K., Sasaki, T., Okochi, K., Yamasaki, S., Saito, T., Takayama, H. and Yokosawa, H.: Differential display analysis reveals the expression of glutathione S-transferase and novel genes through an ITAM-containing receptor in ascidian immunocytes. Immunogenetics 57(6);444-452, 2005. 7. Hida, S., Tadachi, M., Saito, T. and Taki, S.: Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-2019, 2005. 8. Taki, S., Nakajima, S., Ichikawa, E., Saito, T. and Hida, S.: IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J. Immunol. 174; 6005-6012, 2005. 9. Linwong, W., Hirasawa, N., Aoyama, S., Hamada, H., Saito, T. and Ohuchi, K.: Inhibition of the antigen-induced activation of rodent maset cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br. J. Pharmacol. 145; 818-828, 2005. 10. Breij, E. C.W., Heijnen, P., Vloet, R., Saito, T., van de Winkel, J.G.J., Dijkstra, C. D., Amor, S. and Verbeek, S.: The FcR chain is not essential for induction of experimental allergic encephalomyelitis (EAE) or anti-myelin antibody-mediated exacerbation of EAE. J. Neuropathol. Exp. Neurol. 64(4); 304-311, 2005. 11. Kataoka, H., Takahashi, S., Takase, K., Yamasaki, S., Yokosuka, T., Koike, T. and Saito, T.: CD25+CD4+ regulatory T cells exert in vitro suppressive activity independently of CTLA-4. Int. Immunol. 17(4); 421-427, 2005. 12. Takahashi, S., Kataoka, H., Hara, S., Yokosuka, T., Takase, K., Yamasaki, S., Kobayashi, W., Saito, Y. and Saito, T.: In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection. Eur. J. Immunol. 35:399-407, 2005. 13. Suzuki, N., Suzuki, S. and Saito, T.: IRAKs: key regulatory kinases of innate immunity. Curr. Med. Chem. 4(1): 13-20, 2005. 14. Kohno, M., Yamasaki, S., Tybulewicz, VL. and Saito, T.: Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood. 105(5); 2059-2065, 2005.(the first two authors equally contributed.) 2004 1. Yamasaki, S. and Saito, T.: Inhibitory adaptors in lymphocytes. Semin. Immunol. 16(6): 421-427, 2004. 2. Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Xu W, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K.: The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int. Immunol. 16(12): 1691-9, 2004. 3. Hara, H., Bakai, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T. and Penninger, J. M.: The molecular adapter Carma1 controls entry of IKK into the central immune synapse. J. Exp. Med. 200(9):1167-1177, 2004. 4. Nakatsu, F., Okada, M., Mori, F., Kumazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T., Watanabe, M., Yuasa, S., Manabe, T., Wakabayashi, K., Kaneko, S., Saito, T., and Ohno, H.: Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J.Cell. Biol. 167(2): 293-302, 2004. 5. Tomassini, B., Malisan, F., Franchi, L., Nicolo, C., Brea-Calvo, G., Saito, T. and Testi, R.: Calnexin suppresses GD3 synthase-induced apoptosis. FASEB J. 18(13): 1553-1555, 2004. 6. Ishikawa, S., Arase, N., Suenaga, T., Saita, Y., Noda, M., Kuriyama, T., Arase, H. and Saito, T.: Involvement of FcRg in signal transduction of osteoclast-associated receptor (OSCAR). Int. Immunol. 16(7): 1019-1025, 2004. 7. Ohtsuka, M., Arase, H., Takeuchi, A., Yamasaki, S., Shiina, R., Suenaga, T., Sakurai, D., Yokosuka, T., Arase, N., Iwashima, M., Kitamura, T., Moriya, H., and Saito, T.: NFAM1, a new ITAM+ surface molecule that regulates development and signaling of B lymphocytes. Proc. Natl. Acad. Sci. USA 101(21): 8126-8131, 2004. 8. Ishizuka, M., Toyama, Y., Watanabe, H., Fujiki, Y., Takeuchi, A., Yamasaki, S., Yuasa, S., Miyazaki, M., Nakajima, N., Taki, S. and Saito, T.: Overexpression of human acyl CoA thioesterase upregulates peroxisome biogenesis. Exp. Cell. Res. 297(1): 127-141, 2004. 9. Yamasaki, S., Ishikawa, E., Kohno, M. and Saito, T.: The quantity and duration of FcR gamma signals determines mast cell degranulation and survival. Blood. 103(8): 3093-3101, 2004. 10. Kuroyama, H., Ikeda, T., Kasai, M., Yamasaki, S., Tatsumi, M., Utsuyama, M., Saito, T. and Hirokawa, K.: Identification of a novel isoform of ZAP-70, truncated ZAP kinase. Biochem. Biophys. Res. Commun. 315(4): 935-941, 2004. 11. Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L.: Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 199(4): 525-533, 2004. 12. Sakurai, D., Yamasaki, S., Arase, K., Park, S. Y., Arase, H., Konno, A. and Saito, T.: Fc epcilon RI gamma-immunoreceptor tyrosine-based activation motif is differentially required for mast cell function in vivo. J. Immunol. 172(4): 2374-2381 2004.