Immune Surveillance Research Unit
P.J.Bryce, C.Mathias, K.Harrison, T.Watanabe, R.S.Geha, H.Oettgen. The H1 histamine receptor regulates allergic lung responses. J. Clin. Invest. 116:1624-1632, 2006 Zhi-Li Huang, T.Mochizuki, Wei-Min Qu, Zong-Yuan Hong, T.Watanabe, Y.Urade, and O,Hayaishi. Alterations of sleep-wake behavioral characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc. Natl. Acad. Sci. USA 103: 4687-4692, 2006. H. K.Takahashi, T.Watanabe, A.Yokoyama, H.Iwagaki, T.Yoshino, N.Tanaka and M.Nishibori: Cimetidine induces IL-18 production through H2-agonist activity in monocytes.Mol. Pharmcology 70: 450-453, 2006 F. Ishikawa, M.Yasukawa, B.Lyons, S.Yoshida, T.Miyamoto, G.Yoshimoto, T.Watanabe, K.Akashi, L.D.Shultz, M.Harada: Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain null mice. Blood 106:1565-1573, 2005 K.Sonoda, S.Miyamoto, T.Hirakawa, H.Yagi, F.Yotsumoto, M.Nakashima, T.Watanabe, H.Nakano: Invasive potency related to RCAS1 expression in uterine cervical cancer.Gynecologic Oncology 99:189-198, 2005. K.Sonoda, S.Miyamoto, T.Hirakawa, H.Yagi, F.Yotsumoto, M.Nakashima, T.Watanabe, H.Nakano: Association between RCAS1 expression and microenvironmental immune cell death in uterine cancer. Gynecologic Oncology 97:772-779, 2005. S. Suematsu and T. Watanabe: Generation of synthetic lymphoid tissue-like organoid in mice. Nature Biotechnology 22: 1539-1545, 2004. S. Adams, G. T. Miller, M.I. Jesson, T. Watanabe, B. Jones, B.P. Wallner: PT-100, A small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Research 64:5471-5480, 2004. Y. Ide, D. Tsuchimoto, Y. Tominaga, M. Nakashima, T. Watanabe, Sakumi, M. Ohno, and Y.Nakabeppu: Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood 104: 4097-4103, 2004 K.Muta, K.Ohshima, Y.Abe, N.Uike, I.Choi, T.Matsushima, J.Nishimura, M.Kikuchi, M.Nakashima, T.Watanabe, H.Nawata: Expression of human tumor-associated antigen RCAS1 in adult T-cell leukemia/lymphoma. International J. Hematology 79: 340-344, 2004 J.Otsuka, T.Horiuchi, S.Yoshizawa, H.Tsukamoto, T.Sawabe, Y.Kikuchi, D.Himeji, T.Koyama, H.Mitoma, T.Watanabe, M.Harada: Association of a four-amino-acid- residue-insertion polymorphism of the HS1 gene with systemic lupus erythematosus: Molecular and functional analysis. Arthritis and Rheumatism 50: 871-881, 2004 M.Yokoyama, A.Yokoyama, S.Mori, H.K.Takahashi, T.Yoshino, T.Watanabe, T.Watanabe, H.Ohtsu, M.Nishibori: Inducible histamine protects mice from P.acnes -primed and LPS-induced hepatitis through H2-receptor stimulation. Gastroenterology 127: 892-902, 2004 C.Teuscher, M.E.Poynter, H.Offiner, A.Zamora, T.Watanabe, P.D.Fillmore, J.F.Zachary, E.P.Blankenhorn: Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice due to dysregulation of cytokine production by antigen presenting cells. American J. of Pathology 104: 883-891, 2004